El ácido fólico y las vitaminas B6 y B12 no reducen los eventos cardiovasculares en mujeres de alto riesgo
Un estudio publicado en JAMA no muestra que la suplementación sea beneficiosa, auque ésta disminuya los niveles de homocisteína ¿Se debe continuar con los ensayos o cerrar definitivamente este capítulo?.
Artículos de referencia:
Albert CM, Cook NR, Gaziano JM, Zaharris E, Macafayden J, et al. Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular cisease. A randomized trial. JAMA.2008;299(17):2027-2036.
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3. Bazzano LA, Reynolds K, Holder KN, He J. Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials. JAMA. 2006;296(22):2720-26.
4. Carlsson CM. Lowering homocysteine for stroke prevention. Lancet. 2007;369(9576):1841-42.
5. Lonn E, Yusuf S, Arnold MJ, et al. Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med. 2006;354(15):1567-77.
6. Toole JF, Malinow MR, Chambless LE, et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the vitamin intervention for stroke prevention (VISP) randomized controlled trial. JAMA. 2004;291(5):565-75.
Fuente: Suplemento Impacto de la Agencia de Calidad del Sistema Nacional de Salud. Octubre 2008;1(8). Actualidad.
